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The estrogen transdermal patch shortage—driven by a convergence of surging demand, limited manufacturers, tariff pressures on overseas production, and the ripple effects of Bayer’s 2023 discontinuation of its Climara patch—has created a real-time access crisis for women on stable HRT regimens

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These findings suggest a nutrient-gene interaction between selenium and a functional polymorphism in the human GPX1 gene that may contribute to disease [35, 36]